The June issue of the Journal of the American Medical Association (JAMA) includes new research on the burden of opioid-related death in the United States between January 1, 2001 and December 31, 2016. The authors, based in Toronto, conducted a serial cross-sectional study to look at how premature deaths from opioid use have impacted sub-sects of the US population. The authors concluded that “between 2001 and 2016, the number of opioid-related deaths in the United States increased by 345%, from 9,489 to 42,245 deaths.” Men accounted for 67.5% of opioid deaths at an average age of 40 and overall the age group of 24 to 35 was found to bear the majority of the burden. Targeted education and supported is needed to address these groups most in need.